The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Id http://purl.obolibrary.org/obo/dinto_DB01382
http://purl.obolibrary.org/obo/dinto_DB01382
Preferred Name

glycodiazine
Synonyms
C13H15N3O4S
N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
glycodiazine
label
glycodiazine
DBSynonym
glymidine
glidiazine
ATCCode
A10BC01
Definition
Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin. It is used for the concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
has pharmacological target
induces
type
InChIKey
InChIKey=QFWPJPIVLCBXFJ-UHFFFAOYSA-N
Synonym
C13H15N3O4S
N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
xref
PubChem Compound:9565
PharmGKB:PA164748839
PubChem Substance:46507076
ChemSpider:9190
CASRN
339-44-6
prefixIRI
obo2:dinto_DB01382
related with
SMILES
COCCOC1=CN=C(NS(=O)(=O)C2=CC=CC=C2)N=C1
may interact with
InChI
InChI=1S/C13H15N3O4S/c1-19-7-8-20-11-9-14-13(15-10-11)16-21(17,18)12-5-3-2-4-6-12/h2-6,9-10H,7-8H2,1H3,(H,14,15,16)
subClassOf
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