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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB01359
http://purl.obolibrary.org/obo/dinto_DB01359
|
|---|---|
| Preferred Name | penbutolol |
| Synonyms |
C18H29NO2
tert-butyl[(2S)-3-(2-cyclopentylphenoxy)-2-hydroxypropyl]amine
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | penbutolol
|
|---|---|
| label | penbutolol
|
| DBSynonym |
1-(tert-butylamino)-3-(o-cyclopentylphenoxy)propan-2-ol
hoe 893d
2-propanol, 1-(2-cyclopentylphenoxy)-3-((1,1-dimethylethyl)amino)-, (s)-
(2s)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol
penbutololum [inn-latin]
hoe 893
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|
| ATCCode | C07AA23
|
| Definition | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high binding affinity to the 5-hydroxytryptamine receptor 1A with antagonistic effects. This binding characteristic of penbutolol is being investigated for its implications in Antidepressant Therapy. Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity.
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| DBSalt | penbutolol sulfate
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| has pharmacological target | |
| type | |
| InChIKey | InChIKey=KQXKVJAGOJTNJS-HNNXBMFYSA-N
|
| blocks | |
| Synonym |
C18H29NO2
tert-butyl[(2S)-3-(2-cyclopentylphenoxy)-2-hydroxypropyl]amine
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| xref |
PubChem Substance:46504929
Wikipedia:http://en.wikipedia.org/wiki/Penbutolol
Drugs.com:http://www.drugs.com/cdi/penbutolol.html
PharmGKB:PA164749474
PubChem Compound:37464
National Drug Code Directory:0091-4500-15
ChemSpider:34369
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| CASRN | 36507-48-9
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| prefixIRI | obo2:dinto_DB01359
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| related with | |
| SMILES | CC(C)(C)NC[C@H](O)COC1=CC=CC=C1C1CCCC1
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| may interact with |
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| InChI | InChI=1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m0/s1
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| DBBrand |
betapressin
levatol
levatolol
lobeta
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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