The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Id http://purl.obolibrary.org/obo/dinto_DB01289
http://purl.obolibrary.org/obo/dinto_DB01289
Preferred Name

glisoxepide
Synonyms
C20H27N5O5S
N-{2-[4-({[(azepan-1-yl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-5-methyl-1,2-oxazole-3-carboxamide
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
glisoxepide
label
glisoxepide
ATCCode
A10BB11
Definition
Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide, by 4,4 -diisothiocyano-2,2 -stilbenedisulfonate (DIDS) and by sulphate. These results are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid cholate. (PMID:1618280, 9017793)
has pharmacological target
inhibits
type
InChIKey
InChIKey=ZKUDBRCEOBOWLF-UHFFFAOYSA-N
Synonym
C20H27N5O5S
N-{2-[4-({[(azepan-1-yl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-5-methyl-1,2-oxazole-3-carboxamide
xref
PubChem Compound:32778
PubChem Substance:46508780
PharmGKB:PA164743233
ChemSpider:30380
CASRN
25046-79-1
prefixIRI
obo2:dinto_DB01289
SMILES
CC1=CC(=NO1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN1CCCCCC1
may interact with
InChI
InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27)
subClassOf
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