loading...| Preferred Name |
abatacept |
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| Synonyms |
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|
| ID |
http://purl.obolibrary.org/obo/dinto_DB01281 |
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| AHFScode |
92:00.00 |
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| ATCCode |
L04AA24 |
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| binds | ||
| blocks | ||
| CASRN |
332348-12-6 |
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| DBBrand |
orencia |
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| DBSynonym |
ctla4igg4m bms-188667 rg-2077 rg-1046 ctla4-igg4m rg1046 ctla4ig ctla4-ig rg2077 |
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| Definition |
Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). It is produced through recombinant DNA technology in mammalian cells. The drug has activity as a selective costimulation modulator with inhibitory activity on T lymphocytes. Although approved for the treatment of rheumatoid arthritis, Repligen has entered a slightly different formulation of CTLA4-Ig into clinical trials (RG2077). |
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| has pharmacological target | ||
| label |
abatacept |
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| may interact with |
http://purl.obolibrary.org/obo/CHEBI_9513 http://purl.obolibrary.org/obo/dinto_DB06674 |
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| modulates | ||
| prefixIRI |
obo2:dinto_DB01281 |
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| prefLabel |
abatacept |
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| xref |
RxList:http://www.rxlist.com/cgi/generic/orencia.htm PharmGKB:PA164747080 National Drug Code Directory:0003-2187-10 Wikipedia:http://en.wikipedia.org/wiki/Abatacept Drugs Product Database (DPD):2282097 Drugs.com:http://www.drugs.com/cdi/abatacept.html |
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| subClassOf |