The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

galsulfase
Synonyms
ID

http://purl.obolibrary.org/obo/dinto_DB01279
ATCCode

A16AB08
binds

http://purl.obolibrary.org/obo/dinto_0146

http://purl.obolibrary.org/obo/dinto_2269
CASRN

552858-79-4
DBBrand

naglazyme

naglazyme (biomarin pharmaceuticals)
Definition

Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family.
has pharmacological target

http://purl.obolibrary.org/obo/dinto_0146

http://purl.obolibrary.org/obo/dinto_2269
label

galsulfase
prefixIRI

obo2:dinto_DB01279
prefLabel

galsulfase
related with

http://purl.obolibrary.org/obo/dinto_0146

http://purl.obolibrary.org/obo/dinto_2269
xref

Wikipedia:http://en.wikipedia.org/wiki/Galsulfase

PharmGKB:PA164746235

Drugs.com:http://www.drugs.com/cdi/galsulfase.html

RxList:http://www.rxlist.com/cgi/generic/naglazyme.htm
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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