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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB01267
http://purl.obolibrary.org/obo/dinto_DB01267
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|---|---|
| Preferred Name | paliperidone |
| Synonyms |
C23H27FN4O3
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | paliperidone
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|---|---|
| label | paliperidone
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| DBSynonym | 9-hydroxyrisperidone
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| ATCCode | N05AX13
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| Definition | Paliperidone is the primary active metabolite of the older antipsychotic risperidone. While its specific mechanism of action is unknown, it is believed that paliperidone and risperidone act via similar if not the same pathways. It has been proposed that the drug s therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006.
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| has effect |
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| has pharmacological target | |
| activates | |
| type | |
| InChIKey | InChIKey=PMXMIIMHBWHSKN-UHFFFAOYSA-N
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| blocks |
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| AHFScode | 28:16.08.04
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| Synonym | C23H27FN4O3
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
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| xref |
PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam
Wikipedia:http://en.wikipedia.org/wiki/Paliperidone
PharmGKB:PA163518919
PubChem Substance:46506296
PubChem Compound:115237
National Drug Code Directory:50458-554-01
ChemSpider:103109
RxList:http://www.rxlist.com/cgi/generic/invega.htm
Drugs.com:http://www.drugs.com/cdi/paliperidone.html
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| CASRN | 144598-75-4
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| prefixIRI | obo2:dinto_DB01267
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| related with | |
| SMILES | CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCC(O)C2=N1
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| may interact with |
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| InChI | InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
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| DBBrand | invega
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| subClassOf |
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| No notes to display |