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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB01262
http://purl.obolibrary.org/obo/dinto_DB01262
|
|---|---|
| Preferred Name | decitabine |
| Synonyms |
C8H12N4O4
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | decitabine
|
|---|---|
| label | decitabine
|
| DBSynonym |
azadc
dezocitidine
5-aza-2'-deoxycytidine
|
| Definition | Decitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS). It is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of Decitabine incorporate it into DNA during replication and RNA during transcription. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate.
|
| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=XAUDJQYHKZQPEU-KVQBGUIXSA-N
|
| Synonym |
C8H12N4O4
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
|
| xref |
PubChem Compound:451668
Wikipedia:http://en.wikipedia.org/wiki/Decitabine
Drugs.com:http://www.drugs.com/cdi/decitabine.html
National Drug Code Directory:62856-600-01
ChEBI:50131
ChemSpider:397844
PubChem Substance:46505657
PharmGKB:PA164749631
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|
| CASRN | 2353-33-5
|
| prefixIRI | obo2:dinto_DB01262
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| related with | |
| SMILES | NC1=NC(=O)N(C=N1)[C@H]1C[C@H](O)[C@@H](CO)O1
|
| InChI | InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
|
| DBBrand | dacogen
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |