The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Id http://purl.obolibrary.org/obo/dinto_DB01255
http://purl.obolibrary.org/obo/dinto_DB01255
Preferred Name

lisdexamfetamine
Synonyms
C15H25N3O
(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
lisdexamfetamine
label
lisdexamfetamine
DBSynonym
nrp104
lisdexamfetamine dimesylate
Definition
Lisdexamfetamine (L-lysine-d-amphetamine) is a prodrug of the psychostimulant d-amphetamine coupled with the essential amino acid L-lysine. It was developed so that the amphetamine psychostimulant is released and activated more slowly as the prodrug molecule is hydrolyzed consequently cleaving off the amino acid-during the first pass through the intestines and/or the liver. Amphetamines target the trace amine-associated receptor 1 (TAAR1). Amphetamine is also believed to exert its effects by binding to the monoamine transporters (the dopamine transporter or DAT) and increasing extracellular levels of the biogenic amines dopamine, norepinephrine (noradrenaline) and serotonin.
has pharmacological target
inhibits
type
InChIKey
InChIKey=VOBHXZCDAVEXEY-JSGCOSHPSA-N
blocks
Synonym
C15H25N3O
(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide
xref
PubChem Compound:11597698
PharmGKB:PA164748975
National Drug Code Directory:59417-102-10
Wikipedia:http://en.wikipedia.org/wiki/Lisdexamfetamine
ChemSpider:9772458
RxList:http://www.rxlist.com/cgi/generic/vyvanse.htm
PubChem Substance:46505358
Drugs.com:http://www.drugs.com/cdi/lisdexamfetamine.html
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CASRN
608137-32-2
prefixIRI
obo2:dinto_DB01255
SMILES
C[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](N)CCCCN
may interact with
InChI
InChI=1S/C15H25N3O/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19)/t12-,14-/m0/s1
DBBrand
vyvanse
subClassOf
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