The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

epoprostenol
Synonyms

5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydro-2H-cyclopenta[b]furan-2-ylidene]pentanoic acid

C20H32O5
ID

http://purl.obolibrary.org/obo/dinto_DB01240
activates

http://purl.obolibrary.org/obo/dinto_2806

http://purl.obolibrary.org/obo/dinto_0168
AHFScode

92:00.00
ATCCode

B01AC09
binds

http://purl.obolibrary.org/obo/dinto_2835

http://purl.obolibrary.org/obo/dinto_2806

http://purl.obolibrary.org/obo/dinto_0168

http://purl.obolibrary.org/obo/dinto_2058
CASRN

35121-78-9
DBBrand

flolan
DBSynonym

pgi2

prostaglandin i2

prostacyclin
Definition

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000447

http://purl.obolibrary.org/obo/OAE_0000497

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000905

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001437

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000492

http://purl.obolibrary.org/obo/OAE_0000617

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0001744

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0001360

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000549

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000412

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001268

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0001026

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001340

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000691

http://purl.obolibrary.org/obo/OAE_0001275

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0001200

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0001308

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000606

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000618

http://purl.obolibrary.org/obo/OAE_0001418

http://purl.obolibrary.org/obo/OAE_0000456

http://purl.obolibrary.org/obo/OAE_0001379

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0001044

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0001298

http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target

http://purl.obolibrary.org/obo/dinto_2806

http://purl.obolibrary.org/obo/dinto_2835

http://purl.obolibrary.org/obo/dinto_0168
InChI

InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1
InChIKey

InChIKey=KAQKFAOMNZTLHT-OZUDYXHBSA-N
induces

http://purl.obolibrary.org/obo/dinto_2835
is metabolised by

http://purl.obolibrary.org/obo/dinto_2058
is substrate of

http://purl.obolibrary.org/obo/dinto_2058
label

epoprostenol
may interact with

http://purl.obolibrary.org/obo/dinto_DB00519
modulates

http://purl.obolibrary.org/obo/dinto_2806

http://purl.obolibrary.org/obo/dinto_0168
prefixIRI

obo2:dinto_DB01240
prefLabel

epoprostenol
SMILES

[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)CCCCC)[C@@]1([H])CC(O2)=CCCCC(O)=O
Synonym

5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-hexahydro-2H-cyclopenta[b]furan-2-ylidene]pentanoic acid

C20H32O5
xref

Drugs.com:http://www.drugs.com/cdi/epoprostenol.html

ChEBI:15552

Drugs Product Database (DPD):2230845

PubChem Substance:46507362

RxList:http://www.rxlist.com/cgi/generic/flolan.htm

Wikipedia:http://en.wikipedia.org/wiki/Epoprostenol

PharmGKB:PA449479

National Drug Code Directory:0173-0517-00

ChemSpider:4444093

PubChem Compound:5282411
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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http://purl.bioontology.org/ontology/ATC/B01AC09 ATC LOOM
http://www.co-ode.org/ontologies/galen#Epoprostenol GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.355.255.550.550.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022025 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.469.050.175.725.895.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372513003 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906028587940386 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011464 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10221 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.355.255.100.637.550.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D011464 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D011464 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4024020 VANDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61748 NCIT LOOM
http://bmi.utah.edu/ontologies/hfontology/C0033567 HFO LOOM
http://purl.bioontology.org/ontology/RCD/x01GF RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033567 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0012411 OMIT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021150 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/NCIT_C61748 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/003963 NDDF LOOM
http://www.drugbank.ca/drugs/DB01240 FTC LOOM
http://purl.obolibrary.org/obo/CHEBI_15552 FIDEO LOOM
https://go.drugbank.com/drugs/DB01240 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/8814 RXNORM LOOM