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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB01167
http://purl.obolibrary.org/obo/dinto_DB01167
|
|---|---|
| Preferred Name | itraconazole |
| Synonyms |
C35H38Cl2N8O4
1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | itraconazole
|
|---|---|
| label | itraconazole
|
| DBSynonym |
itz
itraconazolum [latin]
itraconazol [spanish]
itcz
itc
|
| ATCCode | J02AC02
|
| Definition | One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis and aspergillosis. [PubChem]
|
| has effect |
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| has pharmacological target | |
| induces | |
| inhibits |
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| type | |
| InChIKey | InChIKey=VHVPQPYKVGDNFY-ZPGVKDDISA-N
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| is metabolised by | |
| AHFScode | 08:14.08
|
| Synonym | C35H38Cl2N8O4
1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
|
| xref |
Drugs Product Database (DPD):2231347
Drugs.com:http://www.drugs.com/cdi/itraconazole.html
PubChem Substance:46505954
PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/spo1411.shtml
PubChem Compound:55283
National Drug Code Directory:50458-295-15
Wikipedia:http://en.wikipedia.org/wiki/Itraconazole
ChemSpider:49927
RxList:http://www.rxlist.com/cgi/generic/itraconazole.htm
PharmGKB:PA450132
ChEBI:6076
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| CASRN | 84625-61-6
|
| prefixIRI | obo2:dinto_DB01167
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| SMILES | CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=C(Cl)C=C(Cl)C=C2)C=C1
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| may interact with |
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| InChI | InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
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| DBBrand |
sporanox
sporonox
triasporn
itrizole
sporanos
sporal
oriconazole
hyphanox
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| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |