The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Id http://purl.obolibrary.org/obo/dinto_DB01157
http://purl.obolibrary.org/obo/dinto_DB01157
Preferred Name

trimetrexate
Synonyms
5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine
C19H23N5O3
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
trimetrexate
label
trimetrexate
DBSynonym
tmx
trimetrexato [inn-spanish]
trimetrexatum [inn-latin]
tmq
ATCCode
P01AX07
Definition
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. [PubChem]
has effect
has pharmacological target
inhibits
type
InChIKey
InChIKey=NOYPYLRCIDNJJB-UHFFFAOYSA-N
Synonym
5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine
C19H23N5O3
xref
PDB:TMQ
Drugs Product Database (DPD):2065770
PubChem Compound:5583
PubChem Substance:46505247
Wikipedia:http://en.wikipedia.org/wiki/Trimetrexate
PharmGKB:PA451790
National Drug Code Directory:58178-020-10
RxList:http://www.rxlist.com/cgi/generic2/trimetrexate.htm
Drugs.com:http://www.drugs.com/cdi/trimetrexate.html
ChemSpider:5381
BindingDB:18268
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CASRN
52128-35-5
prefixIRI
obo2:dinto_DB01157
SMILES
COC1=CC(NCC2=C(C)C3=C(C=C2)N=C(N)N=C3N)=CC(OC)=C1OC
may interact with
InChI
InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)
DBBrand
neutrexin
subClassOf
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