The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/dinto_DB01026
Preferred Name	ketoconazole
Synonyms	1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one C26H28Cl2N4O4
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	ketoconazole
label	ketoconazole
DBSynonym	ketoconazole [usan:ban:inn:jan] ketocanazole ketoconazolum [inn-latin] 2% ketoconazol [inn-spanish] ketoconazol See more See less
ATCCode	G01AF11 J02AB02 D01AC08
Definition	Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0001101 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0000911 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0001052 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000858 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000402 See more See less
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2157
induces	http://purl.obolibrary.org/obo/dinto_0269
inhibits	http://purl.obolibrary.org/obo/dinto_4171 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2667 http://purl.obolibrary.org/obo/dinto_2157 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_1534 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0266 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465 See more See less
type	http://www.w3.org/2002/07/owl#Class
InChIKey	InChIKey=XMAYWYJOQHXEEK-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901
AHFScode	84:04.08.08 08:14.08
Synonym	1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one C26H28Cl2N4O4
xref	National Drug Code Directory:0145-0003-05 RxList:http://www.rxlist.com/cgi/generic/ketocon.htm PDB:KTN BindingDB:31768 Drugs.com:http://www.drugs.com/cdi/ketoconazole.html ChEBI:48339 PharmGKB:PA450146 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/niz1297.shtml Drugs Product Database (DPD):2237235 Wikipedia:http://en.wikipedia.org/wiki/Ketoconazole See more See less
CASRN	65277-42-1
prefixIRI	obo2:dinto_DB01026
is transported by	http://purl.obolibrary.org/obo/dinto_1440
SMILES	CC(=O)N1CCN(CC1)C1=CC=C(OCC2COC(CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1
may interact with	http://purl.obolibrary.org/obo/dinto_DB00906 http://purl.obolibrary.org/obo/CHEBI_4975 http://purl.obolibrary.org/obo/dinto_DB00683 http://purl.obolibrary.org/obo/CHEBI_8212 http://purl.obolibrary.org/obo/CHEBI_71219 http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_66919 http://purl.obolibrary.org/obo/CHEBI_68478 http://purl.obolibrary.org/obo/CHEBI_391960 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_9943 http://purl.obolibrary.org/obo/dinto_DB00801 http://purl.obolibrary.org/obo/CHEBI_4317 http://purl.obolibrary.org/obo/CHEBI_10100 http://purl.obolibrary.org/obo/dinto_DB00585 http://purl.obolibrary.org/obo/CHEBI_49668 http://purl.obolibrary.org/obo/CHEBI_71940 http://purl.obolibrary.org/obo/CHEBI_68642 http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/CHEBI_66876 http://purl.obolibrary.org/obo/CHEBI_66901 http://purl.obolibrary.org/obo/dinto_DB00541 http://purl.obolibrary.org/obo/CHEBI_4672 http://purl.obolibrary.org/obo/CHEBI_74899 http://purl.obolibrary.org/obo/dinto_DB00243 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_8707 http://purl.obolibrary.org/obo/CHEBI_499361 http://purl.obolibrary.org/obo/CHEBI_520985 http://purl.obolibrary.org/obo/CHEBI_10127 http://purl.obolibrary.org/obo/CHEBI_72690 http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB00540 http://purl.obolibrary.org/obo/dinto_DB01591 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/CHEBI_31401 http://purl.obolibrary.org/obo/CHEBI_31547 http://purl.obolibrary.org/obo/CHEBI_4858 http://purl.obolibrary.org/obo/dinto_DB06207 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_3207 http://purl.obolibrary.org/obo/CHEBI_47499 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_5613 http://purl.obolibrary.org/obo/dinto_DB04855 http://purl.obolibrary.org/obo/CHEBI_3756 http://purl.obolibrary.org/obo/CHEBI_48390 http://purl.obolibrary.org/obo/CHEBI_63634 http://purl.obolibrary.org/obo/dinto_DB06287 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/dinto_DB00214 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/CHEBI_8776 http://purl.obolibrary.org/obo/CHEBI_3611 http://purl.obolibrary.org/obo/CHEBI_68595 http://purl.obolibrary.org/obo/CHEBI_40303 http://purl.obolibrary.org/obo/dinto_DB01410 http://purl.obolibrary.org/obo/dinto_DB00980 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_31794 http://purl.obolibrary.org/obo/dinto_DB00364 http://purl.obolibrary.org/obo/CHEBI_3558 http://purl.obolibrary.org/obo/dinto_DB06702 http://purl.obolibrary.org/obo/dinto_DB00570 http://purl.obolibrary.org/obo/CHEBI_63115 http://purl.obolibrary.org/obo/dinto_DB01357 http://purl.obolibrary.org/obo/dinto_DB06209 http://purl.obolibrary.org/obo/CHEBI_8228 http://purl.obolibrary.org/obo/CHEBI_3761 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_47657 http://purl.obolibrary.org/obo/CHEBI_75045 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/CHEBI_10125 http://purl.obolibrary.org/obo/CHEBI_72296 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_72292 http://purl.obolibrary.org/obo/dinto_DB06212 http://purl.obolibrary.org/obo/dinto_DB01558 http://purl.obolibrary.org/obo/CHEBI_8768 http://purl.obolibrary.org/obo/CHEBI_2611 http://purl.obolibrary.org/obo/CHEBI_6375 http://purl.obolibrary.org/obo/CHEBI_75988 http://purl.obolibrary.org/obo/CHEBI_68579 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_63637 http://purl.obolibrary.org/obo/dinto_DB08901 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_51141 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/CHEBI_480999 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/dinto_DB00440 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_32315 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_73275 http://purl.obolibrary.org/obo/CHEBI_50122 http://purl.obolibrary.org/obo/CHEBI_65173 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/dinto_DB01105 http://purl.obolibrary.org/obo/CHEBI_31236 http://purl.obolibrary.org/obo/CHEBI_39112 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/CHEBI_9168 http://purl.obolibrary.org/obo/dinto_DB00762 http://purl.obolibrary.org/obo/CHEBI_70707 http://purl.obolibrary.org/obo/CHEBI_9139 http://purl.obolibrary.org/obo/CHEBI_31413 http://purl.obolibrary.org/obo/dinto_DB00977 http://purl.obolibrary.org/obo/CHEBI_7915 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_7772 http://purl.obolibrary.org/obo/CHEBI_51450 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/CHEBI_49575 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/dinto_DB00690 http://purl.obolibrary.org/obo/CHEBI_50275 http://purl.obolibrary.org/obo/CHEBI_63584 http://purl.obolibrary.org/obo/dinto_DB01373 http://purl.obolibrary.org/obo/dinto_DB08918 http://purl.obolibrary.org/obo/CHEBI_2896 http://purl.obolibrary.org/obo/CHEBI_119915 http://purl.obolibrary.org/obo/CHEBI_50922 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_27999 http://purl.obolibrary.org/obo/CHEBI_114785 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB01589 http://purl.obolibrary.org/obo/CHEBI_68647 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/CHEBI_63613 http://purl.obolibrary.org/obo/CHEBI_9674 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/CHEBI_71272 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/CHEBI_5383 http://purl.obolibrary.org/obo/dinto_DB01623 http://purl.obolibrary.org/obo/CHEBI_65349 http://purl.obolibrary.org/obo/CHEBI_64318 http://purl.obolibrary.org/obo/CHEBI_4681 http://purl.obolibrary.org/obo/CHEBI_70735 http://purl.obolibrary.org/obo/CHEBI_46295 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_45783 http://purl.obolibrary.org/obo/dinto_DB00951 http://purl.obolibrary.org/obo/CHEBI_2569 http://purl.obolibrary.org/obo/CHEBI_4562 http://purl.obolibrary.org/obo/CHEBI_2666 See more See less
InChI	InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3
DBBrand	ketoisdin nizoral a-d shampoo extina panfungol fungarest orifungal nizoral cream nizoral shampoo nizoral a-d orifungal m ketozole ketoderm fungoral nizoral sebazole See more See less
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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