The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Id http://purl.obolibrary.org/obo/dinto_DB01007
http://purl.obolibrary.org/obo/dinto_DB01007
Preferred Name

tioconazole
Synonyms
1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
C16H13Cl3N2OS
Type http://www.w3.org/2002/07/owl#Class

All Properties

prefLabel
tioconazole
label
tioconazole
DBSynonym
tioconazolum [inn-latin]
tioconazol [inn-spanish]
ATCCode
D01AC07
G01AF08
Definition
Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete s foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
has pharmacological target
inhibits
type
InChIKey
InChIKey=QXHHHPZILQDDPS-UHFFFAOYSA-N
blocks
Synonym
1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
C16H13Cl3N2OS
xref
ChemSpider:5282
PubChem Substance:46508604
PharmGKB:PA164746156
National Drug Code Directory:24385-374-82
PubChem Compound:5482
Wikipedia:http://en.wikipedia.org/wiki/Tioconazole
Drugs.com:http://www.drugs.com/cdi/tioconazole.html
Drugs Product Database (DPD):2217406
RxList:http://www.rxlist.com/cgi/generic3/tioconaz.htm
See more
See less
CASRN
65899-73-2
prefixIRI
obo2:dinto_DB01007
SMILES
ClC1=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=CS1
InChI
InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
DBBrand
tz-3
trosyl
zoniden
trosyd af
trosyd j
fungibacid
monistat 1
vagistat-1
gynecure
gyno-trosyd
trosyd
vagistat
See more
See less
subClassOf
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display