The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_DB00999 http://purl.obolibrary.org/obo/dinto_DB00999
Preferred Name	hydrochlorothiazide
Synonyms	C7H8ClN3O4S2 6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	hydrochlorothiazide
label	hydrochlorothiazide
DBSynonym	dihydrochlorurite dihydroxychlorothiazidum dihydrochlorurit hcz dihydrochlorothiazide hctz dihydrochlorothiazid dihydrochlorothiazidum hydrochlorothiazid hydrochlorthiazide See more See less
ATCCode	C03AA03
Definition	A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0001520 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000913 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0001064 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0001051 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0001195 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0001339 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001378 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000851 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000752 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001465 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000347 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350 See more See less
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0757
inhibits	http://purl.obolibrary.org/obo/dinto_0512 http://purl.obolibrary.org/obo/dinto_0757 http://purl.obolibrary.org/obo/dinto_3399 http://purl.obolibrary.org/obo/dinto_1621 http://purl.obolibrary.org/obo/dinto_0520 http://purl.obolibrary.org/obo/dinto_2115 http://purl.obolibrary.org/obo/dinto_2357 See more See less
type	http://www.w3.org/2002/07/owl#Class
InChIKey	InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N
AHFScode	40:28.20
Synonym	C7H8ClN3O4S2 6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
xref	PharmGKB:PA449899 Drugs Product Database (DPD):2247386 BindingDB:13076 National Drug Code Directory:0378-3603-01 Wikipedia:http://en.wikipedia.org/wiki/Hydrochlorothiazide RxList:http://www.rxlist.com/cgi/generic/hctz.htm Drugs.com:http://www.drugs.com/hctz.html See more See less
CASRN	58-93-5
prefixIRI	obo2:dinto_DB00999
related with	http://purl.obolibrary.org/obo/dinto_3879
SMILES	NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1
may interact with	http://purl.obolibrary.org/obo/dinto_DB01551 http://purl.obolibrary.org/obo/dinto_DB00469 http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_31468 http://purl.obolibrary.org/obo/dinto_DB01356 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB01396 http://purl.obolibrary.org/obo/CHEBI_4495 http://purl.obolibrary.org/obo/dinto_DB00046 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_4681 See more See less
InChI	InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
DBBrand	thiaretic panurin hydrosaluric dichlorosal urodiazin hidrochlortiazid fluvin timolide diclotride esidrex disalunil megadiuril hydrozide dichlotiazid hydrodiuretic caplaril diu-melusin hydril ivaugan nefrix chlorzide hydrothide newtolide dicyclotride dichlorotride neo-codema neoflumen idrotiazide hydrodiuril hydropres apresazide maschitt hypothiazide thiuretic hidroronol drenol bremil direma aquarills jen-diril dichlotride hypothiazid hydro-aquil cidrex microzide thlaretic hidril vetidrex ro-hydrazide servithiazid hidrotiazida chlorosulthiadil aquarius See more See less
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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