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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00998
http://purl.obolibrary.org/obo/dinto_DB00998
|
|---|---|
| Preferred Name | frovatriptan |
| Synonyms |
(3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
C14H17N3O
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | frovatriptan
|
|---|---|
| label | frovatriptan
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| DBSynonym | frovatriptan succinate
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| ATCCode | N02CC07
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| Definition | Frovatriptan (Frova?) is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.[1] Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head. It is available as 2.5 mg tablets.
Frovatriptan has mean terminal elimination half-life of approximately 26 hours, which is substantially longer than other triptans.
Frovatriptan is available only by prescription in the United States, where a secondary New Drug Approval (sNDA) was filed in July 2006[2] and which is currently pending.[3] The FDA anticipates completing its review of this application on or before the current PDUFA (Prescription Drug User Fee Act) review date of August 19, 2007. If the sNDA is approved, Frova? will be the only medication indicated in the U.S. for the short-term prevention of menstrual migraine (MM).
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| has effect |
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| has pharmacological target | |
| activates | |
| type | |
| InChIKey | InChIKey=XPSQPHWEGNHMSK-SECBINFHSA-N
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| is metabolised by | |
| Synonym |
(3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
C14H17N3O
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| xref |
Drugs.com:http://www.drugs.com/cdi/frovatriptan.html
National Drug Code Directory:63481-025-09
ChemSpider:70378
Wikipedia:http://en.wikipedia.org/wiki/Frovatriptan
BindingDB:50073689
PubChem Substance:46506288
PharmGKB:PA164754891
PubChem Compound:77992
PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/fro1622.shtml
RxList:http://www.rxlist.com/cgi/generic3/frova.htm
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| CASRN | 158747-02-5
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| prefixIRI | obo2:dinto_DB00998
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| SMILES | CN[C@@H]1CCC2=C(C1)C1=C(N2)C=CC(=C1)C(N)=O
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| may interact with |
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| InChI | InChI=1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1
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| DBBrand |
frovelan
miguard
frova
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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