Link to this page
The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00976
http://purl.obolibrary.org/obo/dinto_DB00976
|
|---|---|
| Preferred Name | telithromycin |
| Synonyms |
(3aR,4S,7R,9R,10R,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{4-[4-(pyridin-3-yl)-1H-imidazol-1-yl]butyl}-tetradecahydro-1H-oxacyclotetradeca[4,3-d][1,3]oxazole-2,6,8,14-tetrone
C43H65N5O10
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | telithromycin
|
|---|---|
| label | telithromycin
|
| ATCCode | J01FA15
|
| Definition | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections.
|
| has effect |
See more
See less
|
| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=LJVAJPDWBABPEJ-RMNISARHSA-N
|
| is metabolised by | |
| AHFScode | 08:12.12.12
|
| Synonym | (3aR,4S,7R,9R,10R,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{4-[4-(pyridin-3-yl)-1H-imidazol-1-yl]butyl}-tetradecahydro-1H-oxacyclotetradeca[4,3-d][1,3]oxazole-2,6,8,14-tetrone
C43H65N5O10
|
| xref |
PharmGKB:PA10202
Drugs Product Database (DPD):2247520
RxList:http://www.rxlist.com/cgi/generic3/ketek.htm
National Drug Code Directory:0088-2225-41
PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ket1695.shtml
Wikipedia:http://en.wikipedia.org/wiki/Telithromycin
PDB:TEL
Drugs.com:http://www.drugs.com/cdi/telithromycin.html
See more
See less
|
| CASRN | 191114-48-4
|
| prefixIRI | obo2:dinto_DB00976
|
| SMILES | CC[C@@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCN3C=NC(=C3)C3=CC=CN=C3)C(=O)O[C@@]12C)OC
|
| may interact with |
See more
See less
|
| InChI | InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33+,36-,37-,38-,40+,42-,43+/m1/s1
|
| DBBrand | ketek
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |