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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Id | http://purl.obolibrary.org/obo/dinto_DB00934
http://purl.obolibrary.org/obo/dinto_DB00934
|
|---|---|
| Preferred Name | maprotiline |
| Synonyms |
methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9(14),10,12-hexaen-1-yl}propyl)amine
C20H23N
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
maprotiline
|
|---|---|
| prefLabel |
maprotiline
|
| is metabolised by | |
| blocks |
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| Definition |
Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
|
| DBBrand |
psymion
deprilept
ludiomil
|
| ATCCode |
N06AA21
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| modulates |
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| SMILES |
CNCCCC12CCC(C3=CC=CC=C13)C1=CC=CC=C21
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| InChI |
InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
|
| CASRN |
10262-69-8
|
| prefixIRI |
obo2:dinto_DB00934
|
| Synonym |
methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9(14),10,12-hexaen-1-yl}propyl)amine
C20H23N
|
| binds |
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|
| InChIKey |
InChIKey=QSLMDECMDJKHMQ-UHFFFAOYSA-N
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| subClassOf | |
| may interact with |
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| inhibits | |
| related with | |
| is substrate of | |
| type | |
| xref |
IUPHAR:2402
BindingDB:35228
Guide To Pharmacology:2402
National Drug Code Directory:0378-0060-01
Wikipedia:http://en.wikipedia.org/wiki/Maprotiline
PubChem Compound:4011
ChemSpider:3871
Drugs.com:http://www.drugs.com/cdi/maprotiline.html
PubChem Substance:46508358
PharmGKB:PA450322
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| DBSynonym |
maprotilina [inn-spanish]
maprotiline hcl
maprotylina [polish]
maprotilinum [inn-latin]
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| AHFScode |
28:16.04.28
|
| has pharmacological target |
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