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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00783
http://purl.obolibrary.org/obo/dinto_DB00783
|
|---|---|
| Preferred Name | estradiol |
| Synonyms |
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol
C18H24O2
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | estradiol
|
|---|---|
| label | estradiol
|
| DBSynonym |
17beta oestradiol
17?-estradiol
17?-oestradiol
estradiol-17beta
cis-estradiol
beta-estradiol
17?-estra-1,3,5(10)-triene-3,17-diol
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| ATCCode |
G03CA01
L02AA02
G03CA03
L02AA03
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| Definition | Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized. [PubChem]
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| has effect |
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| DBSalt |
estradiol cypionate
estradiol benzoate
estradiol valerate
estradiol acetate
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| has pharmacological target | |
| activates | |
| inhibits |
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| type | |
| InChIKey | InChIKey=VOXZDWNPVJITMN-ZBRFXRBCSA-N
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| is metabolised by |
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| AHFScode | 68:16.04
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| Synonym | (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol
C18H24O2
|
| xref |
Drugs.com:http://www.drugs.com/estradiol.html
Wikipedia:http://en.wikipedia.org/wiki/Estradiol
ChEBI:16469
RxList:http://www.rxlist.com/cgi/generic3/estrogel.htm
PDB:ECO
National Drug Code Directory:0378-1452-01
IUPHAR:1013
PharmGKB:PA449503
BindingDB:17292
Drugs Product Database (DPD):2246969
PubChem Compound:5757
ChemSpider:5554
Guide To Pharmacology:1013
PubChem Substance:46508115
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| CASRN | 50-28-2
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| prefixIRI | obo2:dinto_DB00783
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| is transported by | |
| related with |
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| SMILES | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
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| may interact with |
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| InChI | InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
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| DBBrand |
alora
climara
estrogel
gynodiol
estraderm mx
femtrace
innofem
estring
divigel
estrace
evamist
estrasorb topical
vivelle-dot
elestrin
estraderm tts
femring
estrofem
menostar
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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