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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00781
http://purl.obolibrary.org/obo/dinto_DB00781
|
|---|---|
| Preferred Name | polymyxin b sulfate |
| Synonyms |
C56H98N16O13
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | polymyxin b sulfate
|
|---|---|
| label | polymyxin b sulfate
|
| DBSynonym |
polymyxin b sulphate
polymixin b sulfate
polymyxin b sulfate salt
|
| ATCCode |
S01AA18
S02AA11
A07AA05
J01XB02
S03AA03
|
| Definition | Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
|
| has pharmacological target | |
| type | |
| InChIKey | InChIKey=WQVJHHACXVLGBL-UHFFFAOYSA-N
|
| Synonym | C56H98N16O13
N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide
|
| xref |
Drugs Product Database (DPD):2242485
RxList:http://www.rxlist.com/cgi/generic3/polymyxin.htm
PubChem Compound:4868
PubChem Substance:46507302
Drugs.com:http://www.drugs.com/mtm/polymyxin-b-ophthalmic.html
PharmGKB:PA451027
National Drug Code Directory:55390-139-10
Wikipedia:http://en.wikipedia.org/wiki/Polymyxin_B
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| CASRN | 1405-20-5
|
| prefixIRI | obo2:dinto_DB00781
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| related with | |
| SMILES | CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O
|
| may interact with | |
| InChI | InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)
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| DBBrand | aerosporin
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| subClassOf |
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