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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00762
http://purl.obolibrary.org/obo/dinto_DB00762
|
|---|---|
| Preferred Name | irinotecan |
| Synonyms |
(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
C33H38N4O6
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | irinotecan
|
|---|---|
| label | irinotecan
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| DBSynonym |
cpt-11
camptothecin-11
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| ATCCode | L01XX19
|
| Definition | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin.
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| has effect |
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| DBSalt | irinotecan hydrochloride
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| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=UWKQSNNFCGGAFS-XIFFEERXSA-N
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| is metabolised by |
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| AHFScode | 10:00.00
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| Synonym | (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
C33H38N4O6
|
| xref |
PubChem Substance:46505871
ChemSpider:54825
Wikipedia:http://en.wikipedia.org/wiki/Irinotecan
Drugs.com:http://www.drugs.com/cdi/irinotecan.html
Drugs Product Database (DPD):2231622
National Drug Code Directory:0703-4432-11
PubChem Compound:60838
PharmGKB:PA450085
RxList:http://www.rxlist.com/cgi/generic2/irinot.htm
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| CASRN | 100286-90-6
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| prefixIRI | obo2:dinto_DB00762
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| is transported by | |
| is substrate of | |
| SMILES | CCC1=C2CN3C(=CC4=C(COC(=O)[C@]4(O)CC)C3=O)C2=NC2=C1C=C(OC(=O)N1CCC(CC1)N1CCCCC1)C=C2
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| may interact with |
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| InChI | InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
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| DBBrand | camptosar
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |