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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00541
http://purl.obolibrary.org/obo/dinto_DB00541
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|---|---|
| Preferred Name | vincristine |
| Synonyms |
C46H56N4O10
methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | vincristine
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|---|---|
| label | vincristine
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| DBSynonym |
vincrstine
vcr
vincrystine
leurocristine
indole alkaloid
z-d-val-lys(z)-oh
lcr
vincristine sulfate
vin
vincristina [dcit]
22-oxovincaleukoblastine
vincristinum [inn-latin]
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| ATCCode | L01CA02
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| Definition | Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin s disease, acute erythraemia, and acute panmyelosis.
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| has effect |
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| has pharmacological target | |
| induces | |
| inhibits |
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| type | |
| InChIKey | InChIKey=OGWKCGZFUXNPDA-XQKSVPLYSA-N
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| is metabolised by | |
| AHFScode | 10:00.00
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| Synonym | C46H56N4O10
methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
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| xref |
PharmGKB:PA451879
ChemSpider:5758
Wikipedia:http://en.wikipedia.org/wiki/Vincristine
Drugs Product Database (DPD):2143305
PubChem Compound:5978
ChEBI:28445
RxList:http://www.rxlist.com/cgi/generic3/vincristine.htm
PubChem Substance:46507033
National Drug Code Directory:61703-309-06
Drugs.com:http://www.drugs.com/cdi/vincristine.html
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| CASRN | 57-22-7
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| prefixIRI | obo2:dinto_DB00541
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| is transported by | |
| SMILES | [H][C@@]12N3CC[C@@]11C4=CC(=C(OC)C=C4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@]2([H])CN(C[C@](O)(CC)C2)CCC2=C1NC1=CC=CC=C21)C(=O)OC
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| may interact with |
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| InChI | InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
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| DBBrand |
vincrex
onco tcs
oncovin
vinkristin
vincasar pfs
marqibo
vincristine sulfate pfs
vincasar
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| subClassOf |
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