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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00519
http://purl.obolibrary.org/obo/dinto_DB00519
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|---|---|
| Preferred Name | trandolapril |
| Synonyms |
(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid
C24H34N2O5
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | trandolapril
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|---|---|
| label | trandolapril
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| DBSynonym | trandolaprilum [latin]
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| ATCCode | C09AA10
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| Definition | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
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| has effect |
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| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=VXFJYXUZANRPDJ-WTNASJBWSA-N
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| is metabolised by | |
| AHFScode | 24:32.04
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| Synonym | (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid
C24H34N2O5
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| xref |
RxList:http://www.rxlist.com/cgi/generic3/mavik.htm
PubChem Substance:46508300
PharmGKB:PA451737
Wikipedia:http://en.wikipedia.org/wiki/Trandolapril
PubChem Compound:5484727
National Drug Code Directory:65862-164-01
ChemSpider:4588590
Drugs Product Database (DPD):2239267
PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tar1425.shtml
Drugs.com:http://www.drugs.com/cdi/trandolapril.html
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| CASRN | 87679-37-6
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| prefixIRI | obo2:dinto_DB00519
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| is transported by | |
| SMILES | [H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O
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| may interact with |
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| InChI | InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
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| DBBrand | mavik
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| subClassOf |
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| No notes to display |