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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00476
http://purl.obolibrary.org/obo/dinto_DB00476
|
|---|---|
| Preferred Name | duloxetine |
| Synonyms |
methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine
C18H19NOS
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | duloxetine
|
|---|---|
| label | duloxetine
|
| DBSynonym |
duloxetine hydrochloride
duloxetine hcl
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| ATCCode | N06AX21
|
| Definition | Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company.
Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia.
Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.
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| has effect |
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| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=ZEUITGRIYCTCEM-KRWDZBQOSA-N
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| is metabolised by | |
| Synonym |
methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine
C18H19NOS
|
| xref |
PubChem Substance:46507937
PharmGKB:PA10066
Drugs.com:http://www.drugs.com/cdi/duloxetine-delayed-release-capsules.html
RxList:http://www.rxlist.com/cgi/generic/cymbalta.htm
PubChem Compound:60835
Wikipedia:http://en.wikipedia.org/wiki/Duloxetine
IUPHAR:202
ChEBI:36795
Guide To Pharmacology:202
National Drug Code Directory:54868-5215-2
ChemSpider:54822
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| CASRN | 136434-34-9
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| prefixIRI | obo2:dinto_DB00476
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| SMILES | CNCC[C@H](OC1=CC=CC2=CC=CC=C12)C1=CC=CS1
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| may interact with |
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| InChI | InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
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| DBBrand |
yentreve
cymbalta
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |