The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Id	http://purl.obolibrary.org/obo/dinto_DB00440 http://purl.obolibrary.org/obo/dinto_DB00440
Preferred Name	trimethoprim
Synonyms	C14H18N4O3 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Type	http://www.w3.org/2002/07/owl#Class

prefLabel	trimethoprim
label	trimethoprim
ATCCode	J01EA01
Definition	A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim resistance has been reported. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0001046 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001168 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000438 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000362 See more See less
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1622
induces	http://purl.obolibrary.org/obo/dinto_1440
inhibits	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1622 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1600 http://purl.obolibrary.org/obo/dinto_1221
type	http://www.w3.org/2002/07/owl#Class
InChIKey	InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221
AHFScode	08:36.00
Synonym	C14H18N4O3 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
xref	PubChem Compound:5578 PharmGKB:PA451788 ChemSpider:5376 BindingDB:18069 RxList:http://www.rxlist.com/cgi/generic2/trimeth.htm Drugs Product Database (DPD):2243116 ChEBI:9731 PubChem Substance:46507125 Drugs.com:http://www.drugs.com/cdi/trimethoprim.html National Drug Code Directory:61570-057-01 Wikipedia:http://en.wikipedia.org/wiki/Trimethoprim See more See less
CASRN	738-70-5
prefixIRI	obo2:dinto_DB00440
SMILES	COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC
may interact with	http://purl.obolibrary.org/obo/CHEBI_31348 http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/dinto_DB00650 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/CHEBI_5296 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_44185 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_49662 http://purl.obolibrary.org/obo/CHEBI_8249 http://purl.obolibrary.org/obo/CHEBI_4325 http://purl.obolibrary.org/obo/dinto_DB06268 http://purl.obolibrary.org/obo/CHEBI_5855 http://purl.obolibrary.org/obo/CHEBI_15367 http://purl.obolibrary.org/obo/CHEBI_60761 http://purl.obolibrary.org/obo/dinto_DB01110 http://purl.obolibrary.org/obo/CHEBI_5130 http://purl.obolibrary.org/obo/dinto_DB00684 http://purl.obolibrary.org/obo/dinto_DB00784 http://purl.obolibrary.org/obo/CHEBI_102484 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_8428 http://purl.obolibrary.org/obo/CHEBI_27999 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_46345 http://purl.obolibrary.org/obo/CHEBI_9328 http://purl.obolibrary.org/obo/dinto_DB00622 http://purl.obolibrary.org/obo/CHEBI_4681 See more See less
InChI	InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
DBBrand	idotrim sulfatrim sulfamethoxazole and trimethoprim trimetoprim monotrim cotrim trimanyl trimpex alprim sulmeprim trimogal trimethioprim tiempe oraprim wellcoprim abaprim primsol uretrim syraprim bactin monoprim proloprim triprim trimexazole co-trimoxazole tmp-ratiopharm primosept sulfamethoprim apo-sulfatrim trimeth/sulfa bactramin instalac trimethopriom septra methoprim trimopan priloprim trimpex 200 monotrimin See more See less
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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