The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Id http://purl.obolibrary.org/obo/dinto_DB00410
http://purl.obolibrary.org/obo/dinto_DB00410
Preferred Name

mupirocin
Synonyms
9-{[(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-{[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid
C26H44O9
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
mupirocin
prefLabel
mupirocin
Definition
Mupirocin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. Mupirocin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.
DBBrand
bactoderm
bactroban
centany
bactroban nasal
turixin
ATCCode
D06AX09
R01AX06
SMILES
C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]1CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O
InChI
InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1
CASRN
12650-69-0
prefixIRI
obo2:dinto_DB00410
Synonym
9-{[(2E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-{[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl}oxan-2-yl]-3-methylbut-2-enoyl]oxy}nonanoic acid
C26H44O9
has effect
binds
InChIKey
InChIKey=MINDHVHHQZYEEK-HBBNESRFSA-N
subClassOf
inhibits
type
xref
PubChem Compound:446596
Drugs Product Database (DPD):2239757
National Drug Code Directory:0062-1610-01
PDB:MRC
PubChem Substance:46505594
ChemSpider:393914
Wikipedia:http://en.wikipedia.org/wiki/Mupirocin
RxList:http://www.rxlist.com/cgi/generic/mupi.htm
PharmGKB:PA164764568
Drugs.com:http://www.drugs.com/cdi/mupirocin-cream.html
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DBSynonym
mupirocine
mrc
pseudomonic acid
AHFScode
84:04.04
has pharmacological target
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