The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	conjugated estrogens
Synonyms	sodium (1S,10R,11S,15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-5-yl sulfate C18H21NaO5S
ID	http://purl.obolibrary.org/obo/dinto_DB00286
activates	http://purl.obolibrary.org/obo/dinto_2827
AHFScode	68:16.04
ATCCode	G03CA57
binds	http://purl.obolibrary.org/obo/dinto_0588 http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_1833 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1822 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_0300 http://purl.obolibrary.org/obo/dinto_2827 http://purl.obolibrary.org/obo/dinto_3100 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1780 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1774 http://purl.obolibrary.org/obo/dinto_1815 http://purl.obolibrary.org/obo/dinto_1810 http://purl.obolibrary.org/obo/dinto_4301 http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1322 http://purl.obolibrary.org/obo/dinto_1763 http://purl.obolibrary.org/obo/dinto_0520
CASRN	438-67-5
DBBrand	prempro evex morestin hyhorin premarin tabs premarin conestoral prempro/premphase premarin vaginal par estro
DBSynonym	estrone sulfate estrone sodium sulfate estrone hydrogen sulfate estrone sulfate sodium estrogens estrone estrone hydrogen sulfate estrone sulphate oestrone sulphate sodium estrone sulfate estrone-sulfate
Definition	Conjugated estrogens, a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 ?-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0001013 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000412 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000984 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0001055 http://purl.obolibrary.org/obo/OAE_0001063 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000502 http://purl.obolibrary.org/obo/OAE_0000767 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001052 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0001263 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0000500 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0001044 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000506 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2827
InChI	InChI=1S/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,15-,16+,18+;/m1./s1
InChIKey	InChIKey=VUCAHVBMSFIGAI-ZFINNJDLSA-M
inhibits	http://purl.obolibrary.org/obo/dinto_0588 http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_1833 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1822 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_0300
is metabolised by	http://purl.obolibrary.org/obo/dinto_3100 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0901
is substrate of	http://purl.obolibrary.org/obo/dinto_3100 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1780 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1774 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1815 http://purl.obolibrary.org/obo/dinto_1810 http://purl.obolibrary.org/obo/dinto_4301 http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1822 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1322 http://purl.obolibrary.org/obo/dinto_1763 http://purl.obolibrary.org/obo/dinto_0520
is transported by	http://purl.obolibrary.org/obo/dinto_1780 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1774 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1815 http://purl.obolibrary.org/obo/dinto_1810 http://purl.obolibrary.org/obo/dinto_4301 http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1822 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1322 http://purl.obolibrary.org/obo/dinto_1763 http://purl.obolibrary.org/obo/dinto_0520
label	conjugated estrogens
may interact with	http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB00400 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/dinto_DB00306 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB01355 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/CHEBI_8772 http://purl.obolibrary.org/obo/dinto_DB01354 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB01352 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01586 http://purl.obolibrary.org/obo/dinto_DB01353 http://purl.obolibrary.org/obo/CHEBI_9073
modulates	http://purl.obolibrary.org/obo/dinto_2827
prefixIRI	obo2:dinto_DB00286
prefLabel	conjugated estrogens
SMILES	[Na+].[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])C3=CC=C(OS([O-])(=O)=O)C=C3CC[C@@]21[H]
Synonym	sodium (1S,10R,11S,15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-5-yl sulfate C18H21NaO5S
xref	RxList:http://www.rxlist.com/cgi/generic/conest.htm ChemSpider:9532 PubChem Substance:46505680 PubChem Compound:23667301 Drugs Product Database (DPD):2239655 PharmGKB:PA164754789 Drugs.com:http://www.drugs.com/cdi/conjugated-estrogens.html National Drug Code Directory:0046-0872-93
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/GSSO_006274	GSSO	LOOM
https://go.drugbank.com/drugs/DB00286	MDM	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039237	PDQ	LOOM
http://purl.bioontology.org/ontology/ATC/G03CA57	ATC	LOOM
http://www.drugbank.ca/drugs/DB00286	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0014938	OCHV	LOOM