| Preferred Name |
liothyronine
|
|
| Synonyms |
C15H12I3NO4
(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
|
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| ID |
http://purl.obolibrary.org/obo/dinto_DB00279
|
|
| activates |
http://purl.obolibrary.org/obo/dinto_3533 http://purl.obolibrary.org/obo/dinto_1129
|
|
| AHFScode |
68:36.04
|
|
| ATCCode |
H03AA02
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_1803 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_1815 http://purl.obolibrary.org/obo/dinto_1822 http://purl.obolibrary.org/obo/dinto_1573 http://purl.obolibrary.org/obo/dinto_2129 http://purl.obolibrary.org/obo/dinto_0505 http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3533 http://purl.obolibrary.org/obo/dinto_1129 http://purl.obolibrary.org/obo/dinto_1805 http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1987
|
|
| CASRN |
6893-02-3
|
|
| DBBrand |
tresitope triostat cytomel tertroxin
|
|
| DBSynonym |
t3 liothyronine liothyronine sodium triiodothyronine liothyronin l-liothyronine
|
|
| Definition |
The L-triiodothyronine (T3, liothyronine) thyroid hormone is normally synthesized and secreted by the thyroid gland in much smaller quantities than L-tetraiodothyronine (T4, levothyroxine, L-thyroxine). Most T3 is derived from peripheral monodeiodination of T4 at the 5 position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. [PubChem]
|
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000779
|
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| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_3533 http://purl.obolibrary.org/obo/dinto_1129
|
|
| InChI |
InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
|
|
| InChIKey |
InChIKey=AUYYCJSJGJYCDS-LBPRGKRZSA-N
|
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| induces |
http://purl.obolibrary.org/obo/dinto_1440
|
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_1803 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_1815 http://purl.obolibrary.org/obo/dinto_1822
|
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| is substrate of |
http://purl.obolibrary.org/obo/dinto_1805 http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1815 http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1822 http://purl.obolibrary.org/obo/dinto_1987
|
|
| is transported by |
http://purl.obolibrary.org/obo/dinto_1805 http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1815 http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1822 http://purl.obolibrary.org/obo/dinto_1987
|
|
| label |
liothyronine
|
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/dinto_DB00258 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/dinto_DB01164 http://purl.obolibrary.org/obo/CHEBI_59602 http://purl.obolibrary.org/obo/dinto_DB01432
|
|
| modulates |
http://purl.obolibrary.org/obo/dinto_3533 http://purl.obolibrary.org/obo/dinto_1129
|
|
| prefixIRI |
obo2:dinto_DB00279
|
|
| prefLabel |
liothyronine
|
|
| related with |
http://purl.obolibrary.org/obo/dinto_1573 http://purl.obolibrary.org/obo/dinto_2129 http://purl.obolibrary.org/obo/dinto_0505 http://purl.obolibrary.org/obo/dinto_0217
|
|
| SMILES |
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O
|
|
| Synonym |
C15H12I3NO4 (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
|
|
| xref |
IUPHAR:2634 BindingDB:18860 PubChem Compound:5920 RxList:http://www.rxlist.com/cgi/generic3/liothyronine.htm Drugs.com:http://www.drugs.com/cdi/liothyronine.html PharmGKB:PA164778866 PubChem Substance:46506352 Guide To Pharmacology:2634 National Drug Code Directory:39822-0151-1 PDB:T3 Wikipedia:http://en.wikipedia.org/wiki/Liothyronine ChemSpider:5707 ChEBI:18258 Drugs Product Database (DPD):1919466
|
|
| subClassOf |
http://purl.obolibrary.org/obo/dinto_000055
|
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