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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00278
http://purl.obolibrary.org/obo/dinto_DB00278
|
|---|---|
| Preferred Name | argatroban |
| Synonyms |
(2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid
C23H36N6O5S
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | argatroban
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|---|---|
| label | argatroban
|
| ATCCode | B01AE03
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| Definition | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban.
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| has effect |
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| has pharmacological target | |
| inhibits | |
| type | |
| InChIKey | InChIKey=KXNPVXPOPUZYGB-XYVMCAHJSA-N
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| is metabolised by | |
| AHFScode | 20:12.04.12
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| Synonym | (2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid
C23H36N6O5S
|
| xref |
Drugs Product Database (DPD):2243835
BindingDB:50101744
RxList:http://www.rxlist.com/cgi/generic2/argatroban.htm
PubChem Compound:152951
PubChem Substance:46507650
PharmGKB:PA164745516
Drugs.com:http://www.drugs.com/cdi/argatroban.html
ChemSpider:134807
Wikipedia:http://en.wikipedia.org/wiki/Argatroban
National Drug Code Directory:0007-4407-01
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| CASRN | 74863-84-6
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| prefixIRI | obo2:dinto_DB00278
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| SMILES | C[C@@H]1CCN([C@H](C1)C(O)=O)C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2
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| may interact with | |
| InChI | InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15-,17+,18-/m1/s1
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| subClassOf |
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