loading...| Preferred Name |
pegvisomant |
|
| Synonyms |
|
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB00082 |
|
| AHFScode |
68:30.08 |
|
| ATCCode |
H01AX01 |
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| binds |
http://purl.obolibrary.org/obo/dinto_3682 http://purl.obolibrary.org/obo/dinto_0762 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_3568 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_3864 |
|
| blocks | ||
| CASRN |
218620-50-9 |
|
| DBBrand |
somavert (pfizer inc) |
|
| DBSynonym |
somatotropin precursor pituitary growth hormone growth hormone growth hormone 1 gh-n gh |
|
| Definition |
Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity. |
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| has pharmacological target | ||
| induces | ||
| inhibits |
http://purl.obolibrary.org/obo/dinto_3682 http://purl.obolibrary.org/obo/dinto_0762 http://purl.obolibrary.org/obo/dinto_0291 |
|
| label |
pegvisomant |
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| may interact with | ||
| modulates | ||
| prefixIRI |
obo2:dinto_DB00082 |
|
| prefLabel |
pegvisomant |
|
| xref |
PharmGKB:PA164749630 UniProtKB:P58756 GenBank:AF374232 RxList:http://www.rxlist.com/cgi/generic3/somavert.htm National Drug Code Directory:0009-5176-01 Drugs Product Database (DPD):2272199 |
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| subClassOf |