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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00069
http://purl.obolibrary.org/obo/dinto_DB00069
|
|---|---|
| Preferred Name | interferon alfacon-1 |
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | interferon alfacon-1
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|---|---|
| label | interferon alfacon-1
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| DBSynonym |
methionyl interferon consensus
recombinant methionyl human consensus interferon
cifn
methionyl-interferon-consensus
rcon-ifn
consensus interferon
recombinant consensus interferon
interferon consensus, methionyl
ifn alfacon-1
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| ATCCode | L03AB09
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| Definition | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the molecular construction, and a corresponding synthetic DNA sequence was constructed using chemical synthesis methodology. Interferon alfacon-1 differs from interferon alfa-2b at 20/166 amino acids (88% homology), and comparison with interferon-beta shows identity at over 30% of the amino acid positions. Interferon alfacon-1 is produced in Escherichia coli (E. coli) cells that have been genetically altered by insertion of a synthetically constructed sequence that codes for Interferon alfacon-1. Prior to final purification, Interferon alfacon-1 is allowed to oxidize to its native state, and its final purity is achieved by sequential passage over a series of chromatography columns. This protein has a molecular weight of 19,434 daltons.
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| has pharmacological target | |
| type | |
| binds | |
| AHFScode | 10:00.00
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| xref |
PharmGKB:PA164749376
National Drug Code Directory:0187-2007-06
RxList:http://www.rxlist.com/cgi/generic2/infergen.htm
Drugs Product Database (DPD):2239832
GenBank:J00207
Drugs.com:http://www.drugs.com/cdi/interferon-alfacon-1.html
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| CASRN | 118390-30-0
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| prefixIRI | obo2:dinto_DB00069
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| DBBrand |
advaferon
infergen
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| subClassOf |
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| No notes to display |