The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

insulin glargine
Synonyms
ID

http://purl.obolibrary.org/obo/dinto_DB00047
activates

http://purl.obolibrary.org/obo/dinto_0892

http://purl.obolibrary.org/obo/dinto_2264
AHFScode

68:20.08
ATCCode

A10AE04
binds

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_0892

http://purl.obolibrary.org/obo/dinto_2264
CASRN

160337-95-1
DBBrand

lantus

lantus optiset

lantus solostar
DBSynonym

insulin glargine (rdna origin)
Definition

Insulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism. It is an analogue of human insulin made by replacing the asparagine residue at position A21 of the A-chain with glycine and adding two arginines to the C-terminus (positions B31 and 32) of the B-chain. The resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4. Small amounts of insulin glargine are slowly released from microprecipitates giving the drug a long duration of action (up to 24 hours) and no pronounced peak concentration.
has effect

http://purl.obolibrary.org/obo/OAE_0000879

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000557

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000770

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0001057

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000789

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target

http://purl.obolibrary.org/obo/dinto_0892
induces

http://purl.obolibrary.org/obo/dinto_2651
label

insulin glargine
may interact with

http://purl.obolibrary.org/obo/CHEBI_8214

http://purl.obolibrary.org/obo/CHEBI_3437

http://purl.obolibrary.org/obo/CHEBI_8499

http://purl.obolibrary.org/obo/CHEBI_4856

http://purl.obolibrary.org/obo/CHEBI_63622

http://purl.obolibrary.org/obo/CHEBI_3127

http://purl.obolibrary.org/obo/dinto_DB00373

http://purl.obolibrary.org/obo/CHEBI_238698

http://purl.obolibrary.org/obo/CHEBI_3441

http://purl.obolibrary.org/obo/CHEBI_2904

http://purl.obolibrary.org/obo/dinto_DB01359

http://purl.obolibrary.org/obo/CHEBI_6904

http://purl.obolibrary.org/obo/dinto_DB00052

http://purl.obolibrary.org/obo/CHEBI_2379

http://purl.obolibrary.org/obo/CHEBI_3082

http://purl.obolibrary.org/obo/dinto_DB01580

http://purl.obolibrary.org/obo/CHEBI_7444

http://purl.obolibrary.org/obo/CHEBI_6343

http://purl.obolibrary.org/obo/CHEBI_258351
modulates

http://purl.obolibrary.org/obo/dinto_0892

http://purl.obolibrary.org/obo/dinto_2264
prefixIRI

obo2:dinto_DB00047
prefLabel

insulin glargine
xref

Drugs Product Database (DPD):2245689

Drugs.com:http://www.drugs.com/cdi/insulin-glargine-cartridge-systems.html

Wikipedia:http://en.wikipedia.org/wiki/Insulin_glargine

National Drug Code Directory:0088-2220-60

RxList:http://www.rxlist.com/cgi/generic2/lantus.htm

PharmGKB:PA449992
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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