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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_DB00041
http://purl.obolibrary.org/obo/dinto_DB00041
|
|---|---|
| Preferred Name | aldesleukin |
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | aldesleukin
|
|---|---|
| label | aldesleukin
|
| DBSynonym |
t-cell growth factor
tcgf
il-2
interleukin-2 precursor
|
| ATCCode | L03AC01
|
| Definition | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
|
| has pharmacological target | |
| induces | |
| activates | |
| inhibits | |
| type | |
| AHFScode | 10:00.00
|
| xref |
PharmGKB:PA448081
National Drug Code Directory:0078-0495-61
UniProtKB:P60569
Wikipedia:http://en.wikipedia.org/wiki/Aldesleukin
Drugs Product Database (DPD):2130181
RxList:http://www.rxlist.com/cgi/generic2/aldesleukin.htm
GenBank:M11144
Drugs.com:http://www.drugs.com/cdi/aldesleukin.html
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|
| CASRN | 85898-30-2
|
| prefixIRI | obo2:dinto_DB00041
|
| may interact with | |
| modulates | |
| DBBrand |
proleukin
proleukin (chiron corp)
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |