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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_4311
http://purl.obolibrary.org/obo/dinto_4311
|
|---|---|
| Preferred Name | atp-sensitive inward rectifier potassium channel 12 |
| Synonyms |
kir2.2v
potassium channel, inwardly rectifying subfamily j member 12
irk2
inward rectifier k(+) channel kir2.2v
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | atp-sensitive inward rectifier potassium channel 12
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|---|---|
| label | atp-sensitive inward rectifier potassium channel 12
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| Definition | Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium
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| type | |
| is inhibited by | |
| Synonym |
kir2.2v
potassium channel, inwardly rectifying subfamily j member 12
irk2
inward rectifier k(+) channel kir2.2v
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| OrganismClass | human
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| xref |
UniProt ID:Q14500
DrugBank:1968
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_4311
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| is pharmacological target of | |
| Gene | kcnj12
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| subClassOf |
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| No notes to display |