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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_4269
http://purl.obolibrary.org/obo/dinto_4269
|
|---|---|
| Preferred Name | transient receptor potential cation channel subfamily a member 1 |
| Synonyms |
ankyrin-like with transmembrane domains protein 1
transformation sensitive-protein p120
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | transient receptor potential cation channel subfamily a member 1
|
|---|---|
| label | transient receptor potential cation channel subfamily a member 1
|
| is induced by | |
| Definition | Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system
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| type | |
| Synonym |
ankyrin-like with transmembrane domains protein 1
transformation sensitive-protein p120
|
| OrganismClass | human
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| xref |
UniProt ID:O75762
DrugBank:1944
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_4269
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| is pharmacological target of | |
| Gene | trpa1
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| subClassOf |
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| No notes to display |