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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_4194
http://purl.obolibrary.org/obo/dinto_4194
|
|---|---|
| Preferred Name | poly [adp-ribose] polymerase 3 |
| Synonyms |
nad(+) adp-ribosyltransferase 3
padprt-3
irt1
parp-3
hparp-3
poly[adp-ribose] synthetase 3
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | poly [adp-ribose] polymerase 3
|
|---|---|
| label | poly [adp-ribose] polymerase 3
|
| Definition | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing
|
| type | |
| Synonym |
nad(+) adp-ribosyltransferase 3
padprt-3
irt1
parp-3
hparp-3
poly[adp-ribose] synthetase 3
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|
| OrganismClass | human
|
| xref |
DrugBank:6552
UniProt ID:Q9Y6F1
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_4194
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| related with | |
| Gene | parp3
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| subClassOf |
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