hemagglutinin ha1 chain

fragment

hemagglutinin ha2 chain

http://purl.obolibrary.org/obo/dinto_4166

http://purl.obolibrary.org/obo/dinto_DB07726

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore

DrugBank Database

hemagglutinin

viral

obo2:dinto_4166

hemagglutinin

http://purl.obolibrary.org/obo/dinto_DB07726

hemagglutinin ha1 chain

fragment

hemagglutinin ha2 chain

UniProt ID:P26137

DrugBank:6566

http://purl.obolibrary.org/obo/dinto_000128