Link to this page
The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_4068
http://purl.obolibrary.org/obo/dinto_4068
|
|---|---|
| Preferred Name | potassium voltage-gated channel subfamily kqt member 2 |
| Synonyms |
voltage-gated potassium channel subunit kv7.2
neuroblastoma-specific potassium channel subunit alpha kvlqt2
kqt-like 2
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | potassium voltage-gated channel subfamily kqt member 2
|
|---|---|
| label | potassium voltage-gated channel subfamily kqt member 2
|
| Definition | Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors
|
| type | |
| is inhibited by | |
| Synonym |
voltage-gated potassium channel subunit kv7.2
neuroblastoma-specific potassium channel subunit alpha kvlqt2
kqt-like 2
|
| OrganismClass | human
|
| xref |
DrugBank:1086
UniProt ID:O43526
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_4068
|
| related with | |
| is pharmacological target of | |
| Gene | kcnq2
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |