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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3988
http://purl.obolibrary.org/obo/dinto_3988
|
|---|---|
| Preferred Name | integrin alpha-4 |
| Synonyms |
cd49d antigen
vla-4
integrin alpha-iv
integrin alpha-4 precursor
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | integrin alpha-4
|
|---|---|
| label | integrin alpha-4
|
| Definition | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells
|
| type | |
| is inhibited by | |
| Synonym |
cd49d antigen
vla-4
integrin alpha-iv
integrin alpha-4 precursor
|
| OrganismClass | human
|
| xref |
UniProt ID:P13612
DrugBank:647
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3988
|
| related with | |
| is pharmacological target of | |
| Gene | itga4
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |