The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	mitogen-activated protein kinase 1
Synonyms	mapk 2 p42-mapk ec 2.7.11.24 extracellular signal-regulated kinase 2 ert1 map kinase 2 mitogen-activated protein kinase 2 erk-2
ID	http://purl.obolibrary.org/obo/dinto_3844
binds	http://purl.obolibrary.org/obo/dinto_DB02482 http://purl.obolibrary.org/obo/dinto_DB07794 http://purl.obolibrary.org/obo/dinto_DB02116 http://purl.obolibrary.org/obo/dinto_DB07905 http://purl.obolibrary.org/obo/dinto_DB06877 http://purl.obolibrary.org/obo/dinto_DB04338 http://purl.obolibrary.org/obo/dinto_DB07010 http://purl.obolibrary.org/obo/dinto_DB07264 http://purl.obolibrary.org/obo/dinto_DB08513 http://purl.obolibrary.org/obo/dinto_DB07788 http://purl.obolibrary.org/obo/dinto_DB08521
Definition	Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1
definition source	DrugBank Database
Gene	mapk1
is binded by	http://purl.obolibrary.org/obo/CHEBI_30621 http://purl.obolibrary.org/obo/dinto_DB02733 http://purl.obolibrary.org/obo/dinto_DB01064
is induced by	http://purl.obolibrary.org/obo/dinto_DB01064 http://purl.obolibrary.org/obo/CHEBI_30621
is inhibited by	http://purl.obolibrary.org/obo/dinto_DB02733
is pharmacological target of	http://purl.obolibrary.org/obo/CHEBI_30621
label	mitogen-activated protein kinase 1
OrganismClass	human
prefixIRI	obo2:dinto_3844
prefLabel	mitogen-activated protein kinase 1
related with	http://purl.obolibrary.org/obo/dinto_DB02482 http://purl.obolibrary.org/obo/dinto_DB07794 http://purl.obolibrary.org/obo/dinto_DB02116 http://purl.obolibrary.org/obo/dinto_DB07905 http://purl.obolibrary.org/obo/dinto_DB06877 http://purl.obolibrary.org/obo/dinto_DB04338 http://purl.obolibrary.org/obo/dinto_DB07010 http://purl.obolibrary.org/obo/dinto_DB07264 http://purl.obolibrary.org/obo/dinto_DB08513 http://purl.obolibrary.org/obo/dinto_DB07788 http://purl.obolibrary.org/obo/dinto_DB08521
Synonym	mapk 2 p42-mapk ec 2.7.11.24 extracellular signal-regulated kinase 2 ert1 map kinase 2 mitogen-activated protein kinase 2 erk-2
xref	DrugBank:1176 UniProt ID:P28482
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

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Mapping To	Ontology	Source
http://www.phoc.org.cn/pmo/class/PMO_00020616	PMAPP-PMO	LOOM
http://www.ncbi.nlm.nih.gov/gene/26413	NIFSTD	LOOM
http://purl.obolibrary.org/obo/MESH_D019950	BERO	LOOM
http://www.limics.org/hrdo/rdfns#gen_id_17413	HRDO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019950	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.696.620.682.700.646.750.249.500	RH-MESH	LOOM
http://www.bioassayontology.org/bao#BAO_0002789	BAO	LOOM
http://purl.obolibrary.org/obo/OMIT_0019913	OMIT	LOOM
http://purl.bioontology.org/ontology/MESH/D019950	MESH	LOOM
http://purl.uniprot.org/uniprot/P28482	FTC	LOOM
http://www.drugtargetontology.org/dto/DTO_03100315	DTO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.696.620.682.700.567.342.500	RH-MESH	LOOM
http://purl.jp/bio/4/id/200906004085513623	IOBC	LOOM
http://purl.obolibrary.org/obo/PR_000000103	PR	LOOM
http://purl.obolibrary.org/obo/PR_000000103	NIFSTD	LOOM
http://purl.bioontology.org/ontology/OMIM/176948	OMIM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.476.450.169.500	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.360.450.169.500	RH-MESH	LOOM
http://id.nlm.nih.gov/mesh/D019950	MDM	LOOM
http://purl.obolibrary.org/obo/NCIT_C17589	BERO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17589	NCIT	LOOM
http://www.orpha.net/ORDO/Orphanet_159910	ORDO	LOOM