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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3651
http://purl.obolibrary.org/obo/dinto_3651
|
|---|---|
| Preferred Name | egl nine homolog 2 |
| Synonyms |
hif-prolyl hydroxylase 1
prolyl hydroxylase domain-containing protein 1
ec 1.14.11.-
hph-3
estrogen-induced tag 6
hif-ph1
phd1
hypoxia-inducible factor prolyl hydroxylase 1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | egl nine homolog 2
|
|---|---|
| label | egl nine homolog 2
|
| Definition | Catalyzes the posttranslational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation
|
| type | |
| Synonym |
hif-prolyl hydroxylase 1
prolyl hydroxylase domain-containing protein 1
ec 1.14.11.-
hph-3
estrogen-induced tag 6
hif-ph1
phd1
hypoxia-inducible factor prolyl hydroxylase 1
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|
| OrganismClass | human
|
| xref |
DrugBank:3954
UniProt ID:Q96KS0
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3651
|
| related with | |
| Gene | egln2
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |