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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3644
http://purl.obolibrary.org/obo/dinto_3644
|
|---|---|
| Preferred Name | egl nine homolog 1 |
| Synonyms |
ec 1.14.11.-
phd2
hif-prolyl hydroxylase 2
prolyl hydroxylase domain-containing protein 2
hph-2
hif-ph2
sm-20
hypoxia-inducible factor prolyl hydroxylase 2
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | egl nine homolog 1
|
|---|---|
| label | egl nine homolog 1
|
| Definition | Catalyzes the posttranslational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex
|
| type | |
| Synonym |
ec 1.14.11.-
phd2
hif-prolyl hydroxylase 2
prolyl hydroxylase domain-containing protein 2
hph-2
hif-ph2
sm-20
hypoxia-inducible factor prolyl hydroxylase 2
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|
| OrganismClass | human
|
| xref |
UniProt ID:Q9GZT9
DrugBank:3960
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3644
|
| related with | |
| Gene | egln1
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |