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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3641
http://purl.obolibrary.org/obo/dinto_3641
|
|---|---|
| Preferred Name | egl nine homolog 3 |
| Synonyms |
ec 1.14.11.-
phd3
hif-ph3
hif-prolyl hydroxylase 3
prolyl hydroxylase domain-containing protein 3
hypoxia-inducible factor prolyl hydroxylase 3
hph-1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | egl nine homolog 3
|
|---|---|
| label | egl nine homolog 3
|
| Definition | Catalyzes the posttranslational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism
|
| type | |
| Synonym |
ec 1.14.11.-
phd3
hif-ph3
hif-prolyl hydroxylase 3
prolyl hydroxylase domain-containing protein 3
hypoxia-inducible factor prolyl hydroxylase 3
hph-1
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|
| OrganismClass | human
|
| xref |
DrugBank:3962
UniProt ID:Q9H6Z9
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3641
|
| related with | |
| Gene | egln3
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
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