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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3628
http://purl.obolibrary.org/obo/dinto_3628
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|---|---|
| Preferred Name | voltage-dependent n-type calcium channel subunit alpha-1b |
| Synonyms |
biii
brain calcium channel iii
calcium channel, l type, alpha-1 polypeptide isoform 5
voltage- gated calcium channel subunit alpha cav2.2
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | voltage-dependent n-type calcium channel subunit alpha-1b
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|---|---|
| label | voltage-dependent n-type calcium channel subunit alpha-1b
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| Definition | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the "high-voltage activated" (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons
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| type | |
| is inhibited by | |
| Synonym |
biii
brain calcium channel iii
calcium channel, l type, alpha-1 polypeptide isoform 5
voltage- gated calcium channel subunit alpha cav2.2
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| OrganismClass | human
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| xref |
UniProt ID:Q00975
DrugBank:3970
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_3628
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| is pharmacological target of | |
| is blocked by | |
| Gene | cacna1b
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| subClassOf |
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