The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	tumor necrosis factor
Synonyms	tnf-alpha tumor necrosis factor precursor tumor necrosis factor ligand superfamily member 2 tnf-a cachectin
ID	http://purl.obolibrary.org/obo/dinto_3490
binds	http://purl.obolibrary.org/obo/dinto_DB01296 http://purl.obolibrary.org/obo/dinto_DB00005 http://purl.obolibrary.org/obo/dinto_DB06674 http://purl.obolibrary.org/obo/CHEBI_174690 http://purl.obolibrary.org/obo/dinto_DB08904 http://purl.obolibrary.org/obo/dinto_DB01411 http://purl.obolibrary.org/obo/CHEBI_3638 http://purl.obolibrary.org/obo/dinto_DB00051
Definition	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation
definition source	DrugBank Database
Gene	tnf
is binded by	http://purl.obolibrary.org/obo/dinto_DB00005 http://purl.obolibrary.org/obo/CHEBI_72690 http://purl.obolibrary.org/obo/CHEBI_9513 http://purl.obolibrary.org/obo/dinto_DB06674 http://purl.obolibrary.org/obo/dinto_DB08904 http://purl.obolibrary.org/obo/dinto_DB00065 http://purl.obolibrary.org/obo/dinto_DB00051 http://purl.obolibrary.org/obo/dinto_DB01427
is inhibited by	http://purl.obolibrary.org/obo/CHEBI_72690 http://purl.obolibrary.org/obo/CHEBI_9513 http://purl.obolibrary.org/obo/dinto_DB00065 http://purl.obolibrary.org/obo/dinto_DB01427
is pharmacological target of	http://purl.obolibrary.org/obo/dinto_DB00005 http://purl.obolibrary.org/obo/CHEBI_72690 http://purl.obolibrary.org/obo/CHEBI_9513 http://purl.obolibrary.org/obo/dinto_DB06674 http://purl.obolibrary.org/obo/dinto_DB08904 http://purl.obolibrary.org/obo/dinto_DB00065 http://purl.obolibrary.org/obo/dinto_DB00051
label	tumor necrosis factor
OrganismClass	human
prefixIRI	obo2:dinto_3490
prefLabel	tumor necrosis factor
related with	http://purl.obolibrary.org/obo/dinto_DB01296 http://purl.obolibrary.org/obo/dinto_DB00005 http://purl.obolibrary.org/obo/dinto_DB06674 http://purl.obolibrary.org/obo/CHEBI_174690 http://purl.obolibrary.org/obo/dinto_DB08904 http://purl.obolibrary.org/obo/dinto_DB01411 http://purl.obolibrary.org/obo/CHEBI_3638 http://purl.obolibrary.org/obo/dinto_DB00051
Synonym	tnf-alpha tumor necrosis factor precursor tumor necrosis factor ligand superfamily member 2 tnf-a cachectin
xref	UniProt ID:P01375 DrugBank:777
subClassOf	http://purl.obolibrary.org/obo/dinto_000128

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Tumor_Necrosis_Factor	SEPON	LOOM
http://purl.bioontology.org/ontology/OMIM/191160	OMIM	LOOM
http://www.ncbi.nlm.nih.gov/gene/21926	NIFSTD	LOOM
http://purl.uniprot.org/uniprot/P01375	FTC	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Tumor_Necrosis_Factor	APAONTO	LOOM
http://www.semanticweb.org/hanfei/ontologies/2020/9/untitled-ontology-1306#TumorNecrosisFactor	COVID-19-ONT-PM	LOOM
http://purl.bioontology.org/ontology/LNC/LP15932-4	LOINC	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01473	MIO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/8612007	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/SNMI/F-CB960	SNMI	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20535	NCIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12659	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C20535	BERO	LOOM
http://bmi.utah.edu/ontologies/peontology/C0041368	RAO	LOOM
http://purl.obolibrary.org/obo/PR_000000134	PR	LOOM
http://purl.obolibrary.org/obo/PR_000000134	EUPATH	LOOM
http://purl.obolibrary.org/obo/PR_000000134	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/PR_000000134	HOIP	LOOM
http://purl.obolibrary.org/obo/PR_000000134	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000000134	UPHENO	LOOM
http://www.bioassayontology.org/bao#BAO_0000236	BAO	LOOM
http://purl.obolibrary.org/obo/PR_000000134	OBA	LOOM