loading...| Preferred Name | neuraminidase | |
| Synonyms |
ec 3.2.1.18 |
|
| ID |
http://purl.obolibrary.org/obo/dinto_3434 |
|
| binds |
http://purl.obolibrary.org/obo/dinto_DB03503 http://purl.obolibrary.org/obo/dinto_DB03655 http://purl.obolibrary.org/obo/dinto_DB03721 http://purl.obolibrary.org/obo/dinto_DB03321 http://purl.obolibrary.org/obo/dinto_DB03420 http://purl.obolibrary.org/obo/dinto_DB03257 http://purl.obolibrary.org/obo/dinto_DB02944 http://purl.obolibrary.org/obo/dinto_DB02529 http://purl.obolibrary.org/obo/dinto_DB03991 http://purl.obolibrary.org/obo/dinto_DB02600 |
|
| Definition |
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication |
|
| definition source |
DrugBank Database |
|
| Gene |
na |
|
| label |
neuraminidase |
|
| OrganismClass |
viral |
|
| prefixIRI |
obo2:dinto_3434 |
|
| prefLabel |
neuraminidase |
|
| related with |
http://purl.obolibrary.org/obo/dinto_DB03503 http://purl.obolibrary.org/obo/dinto_DB03655 http://purl.obolibrary.org/obo/dinto_DB03721 http://purl.obolibrary.org/obo/dinto_DB03321 http://purl.obolibrary.org/obo/dinto_DB03420 http://purl.obolibrary.org/obo/dinto_DB03257 http://purl.obolibrary.org/obo/dinto_DB02944 http://purl.obolibrary.org/obo/dinto_DB02529 http://purl.obolibrary.org/obo/dinto_DB03991 http://purl.obolibrary.org/obo/dinto_DB02600 |
|
| Synonym |
ec 3.2.1.18 |
|
| xref |
UniProt ID:P03472 DrugBank:3026 |
|
| subClassOf |