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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3338
http://purl.obolibrary.org/obo/dinto_3338
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|---|---|
| Preferred Name | atp-sensitive inward rectifier potassium channel 1 |
| Synonyms |
potassium channel, inwardly rectifying subfamily j member 1
kir1.1
atp-regulated potassium channel rom-k
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | atp-sensitive inward rectifier potassium channel 1
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|---|---|
| label | atp-sensitive inward rectifier potassium channel 1
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| is induced by | |
| Definition | In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium
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| type | |
| is inhibited by | |
| Synonym |
potassium channel, inwardly rectifying subfamily j member 1
kir1.1
atp-regulated potassium channel rom-k
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| OrganismClass | human
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| xref |
DrugBank:709
UniProt ID:P48048
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_3338
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| related with | |
| is pharmacological target of |
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| is blocked by | |
| Gene | kcnj1
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| subClassOf |
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