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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3321
http://purl.obolibrary.org/obo/dinto_3321
|
|---|---|
| Preferred Name | potassium voltage-gated channel subfamily kqt member 1 |
| Synonyms |
voltage-gated potassium channel subunit kv7.1
iks producing slow voltage-gated potassium channel subunit alpha kvlqt1
kqt-like 1
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | potassium voltage-gated channel subfamily kqt member 1
|
|---|---|
| label | potassium voltage-gated channel subfamily kqt member 1
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| Definition | Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea
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| type | |
| is inhibited by | |
| Synonym |
voltage-gated potassium channel subunit kv7.1
iks producing slow voltage-gated potassium channel subunit alpha kvlqt1
kqt-like 1
|
| OrganismClass | human
|
| xref |
UniProt ID:P51787
DrugBank:741
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| definition source | DrugBank Database
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| prefixIRI | obo2:dinto_3321
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| is pharmacological target of | |
| Gene | kcnq1
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| subClassOf |
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