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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3314
http://purl.obolibrary.org/obo/dinto_3314
|
|---|---|
| Preferred Name | 5'-amp-activated protein kinase catalytic subunit alpha-1 |
| Synonyms |
ec 2.7.11.1
ampk alpha-1 chain
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | 5'-amp-activated protein kinase catalytic subunit alpha-1
|
|---|---|
| label | 5'-amp-activated protein kinase catalytic subunit alpha-1
|
| Definition | Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit
|
| type | |
| Synonym |
ec 2.7.11.1
ampk alpha-1 chain
|
| OrganismClass | human
|
| xref |
DrugBank:748
UniProt ID:Q13131
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3314
|
| related with | |
| is pharmacological target of | |
| Gene | prkaa1
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |