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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3281
http://purl.obolibrary.org/obo/dinto_3281
|
|---|---|
| Preferred Name | cubilin |
| Synonyms |
intestinal intrinsic factor receptor
intrinsic factor-cobalamin receptor
intrinsic factor-vitamin b12 receptor
cubilin precursor
460 kda receptor
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | cubilin
|
|---|---|
| label | cubilin
|
| Definition | Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface
|
| type | |
| transports | |
| Synonym |
intestinal intrinsic factor receptor
intrinsic factor-cobalamin receptor
intrinsic factor-vitamin b12 receptor
cubilin precursor
460 kda receptor
|
| OrganismClass | human
|
| xref |
DrugBank:1224
UniProt ID:O60494
|
| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3281
|
| related with | |
| Gene | cubn
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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| No notes to display |