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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
| Id | http://purl.obolibrary.org/obo/dinto_3229
http://purl.obolibrary.org/obo/dinto_3229
|
|---|---|
| Preferred Name | adp-ribosylation factor 1 |
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel | adp-ribosylation factor 1
|
|---|---|
| label | adp-ribosylation factor 1
|
| Definition | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles
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| type | |
| OrganismClass | human
|
| xref |
UniProt ID:P84077
DrugBank:6316
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| definition source | DrugBank Database
|
| prefixIRI | obo2:dinto_3229
|
| related with |
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| Gene | arf1
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| subClassOf |
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| No notes to display |